DSpace Общество:http://dspace.zsmu.edu.ua/handle/123456789/2272026-04-28T06:21:06Z2026-04-28T06:21:06ZDocking studies of the tetrazolo[1,5-c]quinazolin-(6H)-5-on(thion)s to candida albicans dihydrofolate reductaseAntypenko, O. M.Racimbazafi, L. M.Antypenko, L. M.Антипенко, Олексій Миколайовичhttp://dspace.zsmu.edu.ua/handle/123456789/249392026-04-28T06:13:36Z2014-01-01T00:00:00ZНазвание: Docking studies of the tetrazolo[1,5-c]quinazolin-(6H)-5-on(thion)s to candida albicans dihydrofolate reductase
Авторы: Antypenko, O. M.; Racimbazafi, L. M.; Antypenko, L. M.; Антипенко, Олексій Миколайович2014-01-01T00:00:00ZProspects for the Rapid Delivery of Active Pharmaceutical Ingredients to the Brain for Neuroprotective Action: Examples of Nasal Gel FormulationsBelenichev, I. F.Aliyeva, O. G.Burlaka, B. S.Bukhtiyarova, N. V.Shabelnyk, K. P.Бєленічев, Ігор ФедоровичАлієва, Олена ГеннадіївнаБурлака, Богдан СергійовичБухтіярова, Ніна ВікторівнаШабельник, Костянтин Петровичhttp://dspace.zsmu.edu.ua/handle/123456789/248902026-04-21T12:20:02Z2026-01-01T00:00:00ZНазвание: Prospects for the Rapid Delivery of Active Pharmaceutical Ingredients to the Brain for Neuroprotective Action: Examples of Nasal Gel Formulations
Авторы: Belenichev, I. F.; Aliyeva, O. G.; Burlaka, B. S.; Bukhtiyarova, N. V.; Shabelnyk, K. P.; Бєленічев, Ігор Федорович; Алієва, Олена Геннадіївна; Бурлака, Богдан Сергійович; Бухтіярова, Ніна Вікторівна; Шабельник, Костянтин Петрович2026-01-01T00:00:00ZIn silico safety profiling of triazolo/tetrazoloquinazolinederivatives : computational toxicity assessment for novel anti-inflammatory, venotonic drug developmentAntypenko, L.Shabelnyk, K. P.Lysianska, H. P.Zarutska, M.Maletsky, M. M.Шабельник, Костянтин ПетровичЛисянська, Ганна ПетрівнаМалецький, Микола Миколайовичhttp://dspace.zsmu.edu.ua/handle/123456789/247972026-04-08T06:19:28Z2025-01-01T00:00:00ZНазвание: In silico safety profiling of triazolo/tetrazoloquinazolinederivatives : computational toxicity assessment for novel anti-inflammatory, venotonic drug development
Авторы: Antypenko, L.; Shabelnyk, K. P.; Lysianska, H. P.; Zarutska, M.; Maletsky, M. M.; Шабельник, Костянтин Петрович; Лисянська, Ганна Петрівна; Малецький, Микола Миколайович
Аннотация: Previous molecular docking studies demonstrated that hetaryl/cycloalkyl/spiro [1, 2, 4] triazolo [1,5-c] quinazoline carboxylic acids' salts exhibit superior cyclooxygenase-2 (COX-2) binding affinities, with compounds KB-282 and 488 achieving exceptional performance (-11.9 and -10.4 kcal/mol, respectively). However, clinical development of COX-2-targeting compounds requires comprehensive safety evaluation given documented cardiovascular and hepatotoxicity concerns. This study employed computational toxicity assessment using admetSAR 3.0 to evaluate safety profiles of ten triazolo/tetrazoloquinazoline derivatives alongside three reference compounds across six critical endpoints: cardiotoxicity, hepatotoxicity, neurotoxicity, mutagenicity, respiratory toxicity, and nephrotoxicity. Structure-activity relationships revealed, that spiroindoline-tetrazoloquinazoline scaffolds represent promising platforms for optimization. The integration of molecular docking predictions with toxicity assessment enables rational identification of compounds with balanced efficacy-safety profiles, critical for advancing novel anti-inflammatory and venotonic therapeutics. Further investigation is warranted to validate computational predictions and optimize lead compounds toward preclinical development. Keywords. Spiro[1, 2, 4] triazolo [1,5-c] quinazolines, toxicity prediction, ADMETlab 3.0.2025-01-01T00:00:00ZCultural psychology and financial dignity: a framework for educator retention in wartime Zaporizhzhia, UkraineAntypenko, L.Antypenko, O. M.Brytanova, T. S.Антипенко, Олексій МиколайовичБританова, Тетяна Сергіївнаhttp://dspace.zsmu.edu.ua/handle/123456789/247662026-04-06T06:35:21Z2025-01-01T00:00:00ZНазвание: Cultural psychology and financial dignity: a framework for educator retention in wartime Zaporizhzhia, Ukraine
Авторы: Antypenko, L.; Antypenko, O. M.; Brytanova, T. S.; Антипенко, Олексій Миколайович; Британова, Тетяна Сергіївна
Аннотация: This study presents a culturally-informed approach to educator retention in Zaporizhzhia, Ukraine, during ongoing conflict, addressing both school teachers and university faculty. Based on analysis of Ukrainian mentality and cultural psychology, the approach offers a potentially cost-effective alternative to standard salary reforms by addressing cultural motivators while requiring financial investments by leveraging Ukrainian collective responsibility patterns, family-oriented decision making, traditional educational values, and academic cultural traditions. Our findings suggest that understanding cultural psychology is essential for effective educational policy in emergency contexts across all educational levels, contributing to broader understanding of education's critical role in national development during crisis periods.2025-01-01T00:00:00Z