http://dspace.zsmu.edu.ua/handle/123456789/242 2026-11-15T05:29:51Z http://dspace.zsmu.edu.ua/handle/123456789/26420 Название: The Role and Significance of Oxidative Stress in Inflammatory Periodontal Disease and Contemporary Approaches to Antioxidant Therapy Авторы: Belenichev, I. F.; Popazova, O. O.; Salnykov, V. I.; Bukhtiyarova, N. V.; Ryzhenko, V. P.; Petakh, P.; Kamyshny, O.; Oliynyk, S.; Lee, S.; Kyu-Ho, Yi; Бєленічев, Ігор Федорович; Попазова, Олена Олександрівна; Сальников, Валерій Ігорович; Бухтіярова, Ніна Вікторівна; Риженко, Віктор Павлович Аннотация: Periodontitis is a chronic inflammatory disease driven by dysbiotic biofilms and an exaggerated host immune response, resulting in progressive destruction of periodontal tissues and tooth loss. Increasing evidence suggests that oxidative and nitrosative stress play central roles in disease progression by amplifying inflammation, promoting tissue damage, and impairing repair mechanisms. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) derived from immune cells, mitochondria, and enzymatic pathways contribute to lipid peroxidation, DNA damage, and alveolar bone resorption. These mechanisms help explain persistent inflammation and variable treatment response despite conventional periodontal therapy. This narrative review summarizes current evidence on oxidative stress in periodontitis and evaluates the potential role of antioxidant therapy as an adjunct to standard treatment. Particular emphasis is placed on selenium-containing compounds due to their involvement in glutathione peroxidase activity, thioredoxin systems, and mitochondrial protection. Although antioxidant strategies show promise in improving biochemical and clinical outcomes, current evidence remains heterogeneous. Further well-designed clinical studies are needed to clarify their role in routine periodontal care. 2026-01-01T00:00:00Z http://dspace.zsmu.edu.ua/handle/123456789/26419 Название: Nitric Oxide and Mitochondrial Dysfunction in Chronic Heart Failure: A Narrative Review Авторы: Belenichev, I. F.; Aliyeva, O. H.; Bukhtiyarova, N. V.; Ryzhenko, V. P.; Kyuho, Yi; Бєленічев, Ігор Федорович; Алієва, Олена Геннадіївна; Бухтіярова, Ніна Вікторівна; Риженко, Віктор Павлович Аннотация: Chronic heart failure (CHF) remains a leading cause of hospital admission, disability, and cardiovascular death despite major advances in guideline-directed therapy. Beyond hemodynamic impairment and neurohormonal activation, CHF is increasingly understood as a disorder of endothelial dysfunction, nitrosoredox imbalance, mitochondrial injury, energetic failure, and regulated cell death. Nitric oxide (NO) signaling and mitochondrial homeostasis are interconnected components of this broader pathophysiologic network. Under physiologic conditions, endothelial NO synthase-derived NO contributes to vascular tone, coronary microvascular regulation, and myocardial signaling. In CHF, reduced endothelial NO bioavailability may coexist with increased formation of reactive nitrogen species, particularly in inflammatory and oxidizing conditions. The resulting nitroso-redox imbalance can interact with mitochondrial respiratory dysfunction, altered calcium handling, oxidative stress, and regulated cell death, although the relative contribution of these mechanisms varies across heart failure phenotypes and disease states. Guidelinedirected therapies, including angiotensin-converting enzyme inhibitors, angiotensin receptor-neprilysin inhibitors, sodium-glucose cotransporter 2 inhibitors, evidence-based beta-blockers, and mineralocorticoid receptor antagonists, improve clinical outcomes through established neurohormonal, renal, and hemodynamic mechanisms. Experimental and translational evidence suggests that some of these therapies may also influence endothelial, redox, metabolic, or mitochondrial pathways, although the clinical contribution of these secondary effects remains incompletely defined. These mechanistic observations have also motivated investigation of therapies that more directly target endothelial, redox, or mitochondrial abnormalities. Hypertril (1-(beta-phenylethyl)-4-amino-1,2,4-triazolium bromide) is an investigational compound with reported beta-blocking, NO-related, and metabolic effects in experimental models; however, the available evidence remains predominantly preclinical and does not establish clinical efficacy in human CHF. This narrative review examines NO dysregulation and mitochondrial dysfunction as interconnected components of CHF pathophysiology, considers their relationship to contemporary pharmacotherapy, and discusses the translational limitations and research priorities associated with targeting these pathways. 2026-01-01T00:00:00Z http://dspace.zsmu.edu.ua/handle/123456789/26019 Название: Cardioprotective Effects of Coupled SH/NO System Modulators in a Rat Model of Doxorubicin-Induced Heart Failure Авторы: Ryzhenko, V. P.; Belenichev, I. F.; Popazova, O. O.; Bukhtiyarova, N. V.; Oliynyk, S.; Petakh, P.; Halabitska, I.; Kamyshnyi, O.; Риженко, Віктор Павлович; Бєленічев, Ігор Федорович; Попазова, Олена Олександрівна; Бухтіярова, Ніна Вікторівна Аннотация: Background: The high prevalence of chronic heart failure (CHF) in industrialized countries, alongside its grave consequences—including increased mortality, disability, functional impairment, and reduced quality of life—underscores the urgent need to optimize core medical therapy. In this regard, metabolic cardioprotectants are of particular interest, as their action is aimed at interrupting or mitigating the cascade of adverse metabolic reactions and enhancing the compensatory and adaptive mechanisms of the heart. The aim of this study was to evaluate the effect of sulfur-containing pharmacological agents— namely, N-acetylcysteine (NAC), Heptral, Thiotriazoline, and Angiolin—on selected parameters of the NO and thiol-disulfide systems in the hearts of rats with experimental doxorubicin-induced CHF, followed by an assessment of their cardioprotective efficacy 2026-01-01T00:00:00Z http://dspace.zsmu.edu.ua/handle/123456789/26017 Название: Проведення практичних занять провізорам-слухачам курсів підвищення кваліфікації по ускладненням лікарської терапії Авторы: Білай, Іван Михайлович; Райкова, Т. С.; Демченко, B. О.; Рижов, Олексій Анатолійович; Пашко, О. Є. 2013-01-01T00:00:00Z