http://dspace.zsmu.edu.ua/handle/123456789/227 Fri, 28 Aug 2026 08:33:18 GMT 2026-08-28T08:33:18Z http://dspace.zsmu.edu.ua/handle/123456789/25742 Название: Фармацевтична хімія на сучасному етапі Авторы: Кучеренко, Людмила Іванівна; Портна, Олена Олексіївна; Моряк, З. Б.; Морозова, О. О.; Рогульченко, Г. К. Fri, 01 Jan 2010 00:00:00 GMT http://dspace.zsmu.edu.ua/handle/123456789/25742 2010-01-01T00:00:00Z http://dspace.zsmu.edu.ua/handle/123456789/25713 Название: Orotic Acid-1,2,4-Triazole Hybrids as Potential MMP-2,9 Modulating Wound-Healing Agents: Synthesis, Molecular Docking and Biological Evaluation Авторы: Karpenko, Yu. V.; Parchenko, V. V.; Kucherenko, L. I.; Chetvertak, T.; Bihdan, O. A.; Pukhalska, I. O.; Roik, O.; Safronova, D. M.; Meladze, I. N.; Bushueva, I. V.; Карпенко, Юрій Вікторович; Парченко, Володимир Володимирович; Кучеренко, Людмила Іванівна; Бігдан, Олексій Антонович; Пухальська, Ірина Олександрівна; Сафронова, Дар'я Михайлівна; Меладзе, Ігор Нисанович; Бушуєва, Інна Володимирівна Аннотация: The matrix metalloproteinases MMP-2 and MMP-9 are involved in extracellular matrix remodeling, inflammatory response, and tissue remodeling, and overactivity of certain metalloproteinases may also contribute to chronic wound healing. The aim of this work was to synthesize novel hybrid derivatives of orotic acid and 1,2,4-triazole and investigate them as potential modulators of MMP-2/MMP-9. The structure of the compounds was confirmed by 1H, 13C NMR spectroscopy, LC–MS, and elemental analysis. Pharmacokinetic properties were calculated using SwissADME, and enzyme interactions were characterized using molecular docking strategies, protein–ligand contact analysis, and 100 ns molecular dynamics. The inhibitory effect was also assessed in vitro by fluorimetry at a concentration of 10 μM. The compounds had an acceptable drug-like profile, without violations of Lipinski’s rule and PAINS warnings. The highest affinity for MMP-9 was also found for the three target proteins 17, 19 and 13, which showed values of −9.65, −9.47 and −9.17 kcal/mol, respectively, compared to −8.37 kcal/mol for NNGH. Dynamic molecular analysis confirmed the stability of the 13–MMP-9 complex. Compounds 17 and 13 inhibited MMP-9 by 94.2 ± 4.8% and 85.2 ± 3.8%, respectively, with little effect on MMP-2, whereas compound 19 showed balanced inhibition of MMP-2 and MMP-9 by 74.2 ± 4.4% and 79.2 ± 2.8%, respectively. The results identified 13 and 17 as potential compounds with preferential effects on MMP-9, and 19 as a possible dual inhibitor for wound healing activity studies. Thu, 01 Jan 2026 00:00:00 GMT http://dspace.zsmu.edu.ua/handle/123456789/25713 2026-01-01T00:00:00Z http://dspace.zsmu.edu.ua/handle/123456789/25698 Название: Analysis of educational YouTube channel performance during the COVID-19 pandemic and russia's full-scale invasion of Ukraine: a case study of organic and bioorganic chemistry content for Zaporizhzhia state medical and pharmaceutical university (2019-2025) Авторы: Antypenko, L.; Antypenko, O. M.; Brytanova, T. S.; Антипенко, Олексій Миколайович; Британова, Тетяна Сергіївна Аннотация: The COVID-19 pandemic and russia’s full-scale invasion of Ukraine represent two major disruptive events that have fundamentally altered educational delivery in Ukrainian higher education institutions. This study examines the impact of these events on viewership patterns of an educational chemistry YouTube channel intended to Pharmaceutical, Organic and Bioorganic Chemistry Department of Zaporizhzhia State Medical and Pharmaceutical University (ZSMPhU). YouTube analytics data spanning November 2019 to November 2025 was analyzed, encompassing 311,185 total views across multiple metrics including geographic distribution, traffic sources, device types, subscription dynamics, and content performance. Data interpretation incorporated contextual analysis of affecting Ukrainian higher education. The channel experienced a 4,618% increase in views during the first year of the pandemic (2020), peaking at 89,972 views in 2021. Following the russian invasion in February 2022, views declined progressively: -25% (2022), -42% (2023), and -21% (2024). Geographic analysis revealed increased Ukrainian audience percentage ratio (from 24% to 43% of total views) despite absolute decline, while russian viewership collapsed from 8,630 (2022) to zero (2025). Several unexpected patterns emerged: russian audiences paradoxically peaked in the year of the invasion; external traffic from institutional sources increased during crisis conditions; device-specific engagement patterns suggest differentiated viewing contexts, and videos with embedded russian subtitles were restricted for viewing, while most videos with embedded Ukrainian and English subtitles remained open to all. Channel analytics provide quantitative evidence of war's educational impact on a frontline Ukrainian university, while also revealing institutional adaptive responses and unexpected audience behavior patterns. The data demonstrate both vulnerability to geopolitical disruption and resilience of digital educational resources in maintaining continuity during crisis conditions. Thu, 01 Jan 2026 00:00:00 GMT http://dspace.zsmu.edu.ua/handle/123456789/25698 2026-01-01T00:00:00Z http://dspace.zsmu.edu.ua/handle/123456789/25669 Название: Fiber optic drone cable waste as a resource for pharmaceutical, organic and bioorganic chemistry education Авторы: Antypenko, L.; Antypenko, O.; Brytanova, T.; Антипенко, Олексій Миколайович; Британова, Тетяна Сергіївна Thu, 01 Jan 2026 00:00:00 GMT http://dspace.zsmu.edu.ua/handle/123456789/25669 2026-01-01T00:00:00Z