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http://dspace.zsmu.edu.ua/handle/123456789/23103
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Название: | Main mechanisms of thrombotic complications among patients with community-acquired pneumonia combinedwith coronavirus infection |
Авторы: | Skorokhodova, N. Yatsenko, O. Karaban, A. Скороходова, Наталя Олегівна |
Ключевые слова: | CОVІD-19 SАRS-CоV-2 community-acquired pneumonia mechanisms of complications inflamma-tion thrоmbоtіc complications endothelial dysfunction |
Дата публикации: | 2025 |
Библиографическое описание: | Skorokhodova N. Main mechanisms of thrombotic complications among patients with community-acquired pneumonia combinedwith coronavirus infection / N. Skorokhodova, O. Yatsenko, A. Karaban // ScienceRise: Medical Science. - 2025. - N 1. - С. 14-19. - https://doi.org/10.15587/2519-4798.2025.329831. |
Аннотация: | The review article is devoted to the pathogenesis of complications in patients with community-acquired pneumonia associated with coronavirus infection. The current understanding of the pathogenetic mechanisms of SARS-CoV-2 and the progression of COVID-19 indicates complex changes in the neurohumoral status. Understanding the pathogenetic mechanisms of complications in patients with COVID-19 makes it possible to select biomarkers for risk stratification and understand the clinical context of the disease.
The aim of the study: to determine the main mechanisms of thrombotic complications in patients with community-acquired pneumonia associated with coronavirus infection.
Materials and methods: using the Internet resources of scientometric databases PubMed, Web of Science, and SCOPUS, a retrospective analysis of the literature on this topic for the period 2020-2024 was carried out.
Results: A persistent inflammatory state in severe and critically ill patients with COVID-19 is an important trigger of the coagulation cascade. It is important to remember that thrombotic complications are a sign of severe COVID-19 disease and are associated with multiple organ failure and increased mortality. Therefore, the literature review identified the main pathogenetic mechanisms of complications in patients with COVID-19, which allowed us to select the appropriate laboratory tests necessary to predict the course of the disease. An understanding of the pathophysiology of COVID-19 in terms of immune-mediated inflammation and endothelial dysfunction makes it possible to include more appropriate adjunctive treatments in the patient management regimen. |
URI: | http://dspace.zsmu.edu.ua/handle/123456789/23103 |
Располагается в коллекциях: | Наукові праці. (Фтизіатрія і пульмонологія)
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