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Название: Main mechanisms of thrombotic complications among patients with community-acquired pneumonia combinedwith coronavirus infection
Авторы: Skorokhodova, N.
Yatsenko, O.
Karaban, A.
Скороходова, Наталя Олегівна
Ключевые слова: CОVІD-19
SАRS-CоV-2
community-acquired pneumonia
mechanisms of complications
inflamma-tion
thrоmbоtіc complications
endothelial dysfunction
Дата публикации: 2025
Библиографическое описание: Skorokhodova N. Main mechanisms of thrombotic complications among patients with community-acquired pneumonia combinedwith coronavirus infection / N. Skorokhodova, O. Yatsenko, A. Karaban // ScienceRise: Medical Science. - 2025. - N 1. - С. 14-19. - https://doi.org/10.15587/2519-4798.2025.329831.
Аннотация: The review article is devoted to the pathogenesis of complications in patients with community-acquired pneumonia associated with coronavirus infection. The current understanding of the pathogenetic mechanisms of SARS-CoV-2 and the progression of COVID-19 indicates complex changes in the neurohumoral status. Understanding the pathogenetic mechanisms of complications in patients with COVID-19 makes it possible to select biomarkers for risk stratification and understand the clinical context of the disease. The aim of the study: to determine the main mechanisms of thrombotic complications in patients with community-acquired pneumonia associated with coronavirus infection. Materials and methods: using the Internet resources of scientometric databases PubMed, Web of Science, and SCOPUS, a retrospective analysis of the literature on this topic for the period 2020-2024 was carried out. Results: A persistent inflammatory state in severe and critically ill patients with COVID-19 is an important trigger of the coagulation cascade. It is important to remember that thrombotic complications are a sign of severe COVID-19 disease and are associated with multiple organ failure and increased mortality. Therefore, the literature review identified the main pathogenetic mechanisms of complications in patients with COVID-19, which allowed us to select the appropriate laboratory tests necessary to predict the course of the disease. An understanding of the pathophysiology of COVID-19 in terms of immune-mediated inflammation and endothelial dysfunction makes it possible to include more appropriate adjunctive treatments in the patient management regimen.
URI: http://dspace.zsmu.edu.ua/handle/123456789/23103
Располагается в коллекциях:Наукові праці. (Фтизіатрія і пульмонологія)

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