Predictor value cytokines for recurrence of arrhythmia in patients with coronary heart disease combined hypertension and persistent atrial fibrillation

Abstract

Aim of the study was to determine the level of cytokines and Endothelin-1 in patients with coronary heart disease combined with hypertension and persistent atrial fibrillation and to establish the relationship between them in order to evaluate possible predictors of arrhythmia recurrence. Methods: We examined 68 patients with coronary heart disease (CHD) combined with hypertension (HT) and persistent atrial fibrillation (AF) and 23 healthy persons aged from 45 to 65 years. Follow-up period was 18 weeks. Recurrence of atrial fibrillation has been reported in 25 patients. Results: We found that in the group of patients with CHD combined with HT and persistent AF, there was a sharp significant increase in the concentration of interleukin-1β (1.13 ± 0.12) PG/ml, interleukin-4 (0.75 ± 0.06) PG/ml, TNF-alpha (1.66 ± 0.24) PG/ml and endothelin-1 (3.96 ± 0.54) fmol/l in blood plasma in comparison with such indicators of healthy people. The conducted correlation analysis showed an average direct relationship between the level of IL-1β and ET-1 (R= + 0.48, with p < 0.05) and a strong direct relationship between the level of TNF-α and ET-1 R= + 0.79 (p < 0.05) in the group of patients.