Assessment of endothelial nitric oxide synthase activity and oxidative stress markers in pregnant women at high risk for hypertensive disorders

Abstract

The study evaluated the effects of combined prophylactic therapy on nitric oxide system and oxidative stress markers in pregnant women at high risk for hypertensive disorders. Sixty-four participants were randomized to receive standard prophylaxis or additional L-arginine and antioxidant-micronutrient complex (folic acid, vitamin E, docosahexaenoic acid, vitamin D, potassium iodide). After treatment, the combined therapy group showed higher endothelial nitric oxide synthase activity, nitric oxide metabolites, and glutathione reductase activity, indicating improved endothelial function and antioxidant defense.