Effect of endotoxin aggression on development of immune homeostasis damages in infertile men

Abstract

The article deals with the study of endotoxin-antiendotoxin system state showing that endotoxin aggression occurs in infertile men and transforms acute character (in considerable decrease in ejaculate fertility) into chronic one (in absolute deficiency of fertile properties in ejaculate). Changes in the indices of the impaired immune system link indicate an increase in tension, that, apparently assumes alternative available agents (in particular, gram-negative bacteria), which further disrupts spermatogenesis. It is possible to assume that endotoxin aggression, chronic in particular, is an important link of pathogenesis of male infertility, though high LPS concentrations potentiate immune phagocytic link, presumably, as a compensator.