Pathogenetic substantiation of medical immune system correction in parous women with tumor-like formations

Abstract

Endometrioid ovarian cysts in women of childbearing age take a leading position in the structure of gynecological diseases, which is 30 - 40% of cases dramatically reduces the chances of getting pregnant. The methods of treatment applied (surgical, hormonal, anti-inflammatory and others) do not always give the desired effect, so the tactics of treatment for these patients remains controversial. The imbalance between cytopoiesis in the body and timely elimination of altered cells from the body underlies the pathogenesis of genesis of any cysts. Therefore, immune disorders are the cause of formation and functioning of any cysts. On the basis of this, we conducted a study with the objective to identify effective treatment in parous women with ovarian tumor-like formations with consideration for the characteristics of their immune status. Eighty women were surveyed: 50 healthy non-pregnant women, 15 women with a confirmed diagnosis of endometrioid ovarian cyst receiving conventional treatment, 15 women with the same diagnosis who received comprehensive treatment, including the use of immunomodulators and adaptogens Galavit and Indogreen (indole-3-carbinol). Research results showed that in parous women with ovarian tumor-like formations on pretreatment stage irregularities were detected in the immune system, which were manifested by incomplete phagocytosis, decreased neutrophil microbicidal potential, increase in the number of B-lymphocytes and immunoglobulins of basic groups, indicating an impairment of the immune mechanisms of protection of the woman’s body and confirming their involvement in the pathogenesis of the disease. At the end of the traditional course of treatment microbicidal capacity of neutrophils has been still reduced, and there was observed activation of humoral immune system indicating the need for well-grounded immune system correction targeting key pathophysiological processes. Following a comprehensive treatment including the use of immunomodulators and adaptogens Galavit and Indogreen, normalization of the body immune homeostasis took place, which indicates an increase in the effectiveness of the treatment and the possibility for recommending this regimen for future use.