Development of hybrid molecules based on 1,2,4 triazole for combined anticonvulsant therapy

Abstract

The article is devoted to the systematization of modern data on the synthesis of derivatives of 1,2,4-triazole with potential anticonvulsant activity. The unique properties of 1,2,4-triazole as a universal heterocyclic platform that ensures stability, high bioavailability and pharmacological activity are considered. The strategies of molecular modeling of hybrid molecules based on triazole with various pharmacofores that show antiviral, antifungal, antitumor and immunomodulatory properties are analyzed. Particular attention was paid to the Piranian compounds [3,4-C] pyridine nucleus, which found high anticonvulsant, anxiolytic and antidepressant activity. Based on the analysis of literature over the last 10 years, the relationship between structural features, physicochemical characteristics and pharmacological effect has been established. The results create the basis for the development of new anti -epileptic drugs with high efficiency and safety, in particular through purposeful design of molecules.