Review of the latest research on the antiviral potential of 1, 2, 4- triazole derivatives

Abstract

1,2,4-Triazoles are heterocyclic organic compounds with a broad spectrum of biological activity, including antiviral properties. The advantages of 1,2,4-triazole derivatives as a ―core framework‖ for antiviral compounds include chemical stability, which ensures high resistance to hydrolysis and oxidation, sufficiently high bioavailability, and the potential for chemical modification, among others. Therefore, the search for new 1,2,4-triazole derivatives with antiviral activity remains a relevant task in modern pharmaceutical science. The aim of this study was to analyze and summarize global advancements in recent years regarding the study of antiviral properties of 1,2,4-triazole derivatives and to substantiate the necessity and feasibility of further research in this area. 1,2,4-Triazole is a significant heterocyclic ―framework" actively studied in medicine and pharmacy due to its wide range of biological activities, including antiviral properties. Investigating the influence of functional groups in the triazole structure on its antiviral properties enables the development and implementation of effective drugs. Modifying functional groups in the 1,2,4-triazole molecule allows for the modulation of its activity. Careful structural planning using molecular docking and screening methods facilitates the creation of effective medications against various viruses. Conclusion: Global advancements in the study of antiviral properties of 1,2,4-triazole derivatives in recent years have been analyzed and summarized. The necessity and feasibility of further research in this chosen direction of scientific inquiry have been substantiated.