The research of 1,2,4-triazole derivatives hepatoprotective activity under tetracycline and infectious hepatitis

Abstract

Objective: The purpose of this work is to study the hepatoprotective properties of potassium 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate on tetracycline and infectious hepatitis models in chickens. Material and Method: Biochemical examination of blood and liver serum was carried out on intact broiler chickens Cross Cobb 500. All groups of chickens were kept separately in different cages in the same room with the same microclimate parameters in accordance with the established requirements. Result and Discussion: Hepatoprotective effect of potassium 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate was established as a result of research on the model of hepatitis in chickens caused by tetracycline, which was not lower than the referent drug - Thiotriazolin®. The biochemical study results demonstrated hepatoprotective properties of the combination of the above compound with the antibiotic Saroflox®, combination of potassium 2-((4-amino-5- (morpholinomethyl)-4H-1,2,4-triazole-3-yl) thio) acetate with classical antibiotic Enrofloxacin® on the model of infectious hepatitis.