Individual Histologic Lesions and Composite Scores in Implant Biopsies Affect Short-Term and Long-Term Kidney Allograft Function

Abstract

Objectives: Our aim was to evaluate which histologic lesions in a donor kidney were associated with graft function up to 5 years and with its dynamics. Materials and Methods: We retrospectively inves - tigated the association between acute and chronic individual histologic lesions and composite scores in preimplant and postreperfusion biopsies from deceased-donor (n = 101) and living-donor (n = 29) kidneys with initial graft function and function at discharge, at 6 months, and at 5 years and slopes of estimated glomerular filtration rate from discharge to 6 months and from 6 months to 5 years.