Показатели системного воспалительного ответа при неосложненных гипертонических кризах

Abstract

The aim of the study is to improve the results of uncomplicated hypertensive crises treatment at the prehospital stage by studying the state of systemic hemodynamics, determining the balance of the autonomic nervous system, and markers relating to the systemic inflammatory response in patients with hypertension in uncomplicated hypertensive crises. In 2017-2019, an open, prospective and comparative study was conducted and consisted of 206 patients with documented stage II HT, of which 131 patients applied for E.M.S. in the “Municipal Institution Zaporizhzhya Station of Emergency (Ambulance) Medical Assistance of “ of the Zaporizhzhia regional Council and 75 people who had a stable course of the disease and were examined on an outpatiently on the basis of the “Primary health care Center No. 10”. Almost healthy 31 people were examined on the basis of the MI “Regional medical exercises dispensary” of the Zaporizhzhia regional Council. The indicators of systemic inflammatory response among the examined individuals in the study were analyzed. An increase in the concentration of serum proinflammatory markers was demonstrated depending on the stage and degree of BP increase. Increased concentrations of catecholamines are associated with increased blood levels of proinflammatory cytokines such as IL-6 and TNF-б.the level of CRP may reflect the inflammatory process in the intima of blood vessels. Interleukin-1в (IL-1в), which is considered an “early response” factor, has been proven to be involved in energy homeostasis and inflammation.