High Urinary Aspartate Aminotransferase in the Late Posttransplant Period Predicts Rapid, Progressive Decline in Kidney Allograft Function

Abstract

Objectives: Scant information is available on factors for predicting the rate of decline in kidney allograft function beyond 1 year posttransplant. We invest igated whether urinary enzymes (alanine amino transferase, alkaline phosphatase, aspartate aminotransferase, N-acetyl-β-D-hexosaminidase, and γ-glutamyl transpeptidase) in the late postoperative period can predict the decline in estimated glomerular filtration rate. Materials and Methods: In 79 kidney allograft recipients 1 to 17 years after kidney transplant, we assessed a value of urinary enzymes single measurement for predicting the slope of estimated glomerular filtration rate, rapid decline in estimated glomerular filtration rate (> 5 mL/min/1.73 m2/y), and significant decline in estimated glomerular filtration rate (≥ 25% from baseline) during a 2-year period.