Исследование фармакологической активности 4-амино-5-(фуран-2-ил)-4H-1,2,4-триазол-3-тиола при парацетамоловом гепатите

Abstract

The consequences of drug-induced hepatitis are getting more and more serious and acute. We chose a model of drug-induced hepatitis with paracetamol because of the spreading of self-treatment and uncontrolled use of paracetamol. In this connection the investigation of pharmacological action in paracetamol hepatitis is of great interest. The aim of this work was to study hepatoprotective activity of 4-amino-5-(furan-2-il)-4H-1,2,4-triazole-3-thiol in paracetamol hepatitis. We have investigated its anticytolytic and antioxidant effect in this model of hepatitis. The obtained data have shown the efficacy of the given substance compared to the reference drugs, such as thiotriazolin and silibor.