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Please use this identifier to cite or link to this item: http://dspace.zsmu.edu.ua/handle/123456789/10700

Название: Directed Search of Anti-inflammatory Agents among (3HQuinazoline-4-ylidene)hydrazides of N-protected Amino acids and their Heterocyclization Products
Авторы: Martynenko, Yulya Victorivna
Antypenko, Oleksii Mukolayovich
Nosulenko, Inna Stepanivna
Berest, Galina Grigorievna
Kovalenko, Sergiy Ivanovich
Мартиненко, Юлія Вікторівна
Антипенко, Олексій Миколайович
Носуленко, Інна Степанівна
Берест, Галина Григорівна
Коваленко, Сергій Іванович
Ключевые слова: Синтез та протизапальна активність триазолохіназолінів
analysis(3H-quinazoline-4-ylidene)hydrazides N-protected amino acids
[1,2,4]triazolo[1,5-c]quinazolines
anti-inflammatory activity
SAR
molecular docking
Issue Date: 2019
Библиографическое описание: Directed Search of Anti-inflammatory Agents among (3HQuinazoline-4-ylidene)hydrazides of N-protected Amino acids and their Heterocyclization Products / Y. Martynenko, O. Antypenko, I. Nosulenko et al. // Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. – 2019. – V.18. – P.1-12.
Аннотация: (Quinazoline-4-ylidene)hydrazides are valued intermediates in modern organic chemistry, as they are commonly used for the synthesis of substituted [1,2,4]triazolo[1,5-c]quinazolines. Objective: Unknown N-acyl-2-([1,2,4]triazolo[1,5-c]quinazoline-2-yl)-alkyl-(alkaryl-, aryl-)amines were synthesized and evaluated for anti-inflammatory potential. Method: The peculiarities of the synthesized compounds structures were studied by IR-, NMR spectroscopy and chromatography-mass spectrometry and were discussed in detail. Probable molecular mechanisms of activity (inhibition of COX-1 and COX-2) were predicted due to molecular docking. Anti-inflammatory activity of synthesized compounds was determined by their ability to reduce the formalin-induced paw edema in rats. «Diclofenac sodium» was used as reference drug.
Описание: https://orcid.org/0000-0002-7751-4769
URI: http://dspace.zsmu.edu.ua/handle/123456789/10700
Appears in Collections:Наукові праці. (Органічна хімія)

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