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Please use this identifier to cite or link to this item: http://dspace.zsmu.edu.ua/handle/123456789/13766

Название: New liquid chromatography assays for simultaneous quantification of antihypertensives atenolol and valsartan in their dosage forms
Авторы: Peleshok, K.
Piponski, M.
Kovalenko, S.
Ahmed, H.
Abdel-Megied, A.
Ezike, O. F.
Logoyda, L.
Коваленко, Сергій Іванович
Ключевые слова: Atenolo
liquid chromatography
single-pill combinations
valsartan
Issue Date: 2021
Библиографическое описание: New liquid chromatography assays for simultaneous quantification of antihypertensives atenolol and valsartan in their dosage forms / K. Peleshok, M. Piponski, S. Kovalenko, H. Ahmed, A. Abdel-Megied, O. F. Ezike, L. Logoyda // Journal of Separation Science. - 2021. - Vol. 44, № 2. - P. 565-575. - https://doi.org/10.1002/jssc.202000859
Аннотация: Nowadays, various single-pill combinations are used as the best choice in hypertension management. However, these pills made a high challenge to analysts in terms of quality control assays. We have developed three sensitive, selective, fast, simple, green, accurate, precise, and robust isocratic high-performance liquid chromatography methods for simultaneous determination of valsartan and atenolol in dosage forms. To find the appropriate high-performance liquid chromatography conditions for the separation of the examined drugs, various columns, isocratic mobile phase systems were tried, and successful attempts were performed. The used columns proved to be indispensably applicable and gave a shorter analysis time and peak symmetries. This reduction in total run time leads to low solvent consumption and makes all methods more economical. The linearity, accuracy, and precision remained within the acceptable limits. Therefore, all developed methods are suitable for the routine quality control analysis of any pharmaceutical preparation containing the two tested drugs with the proposed chromatographic methods advantages for checking quality during stability studies of their pharmaceutical preparations.
URI: http://dspace.zsmu.edu.ua/handle/123456789/13766
Appears in Collections:Наукові праці. (Органічна хімія)

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