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Please use this identifier to cite or link to this item: http://dspace.zsmu.edu.ua/handle/123456789/14005

Название: Experimental simulation of tuberculosis and its features in rabbits under conditions of isoniazid and N'-(2-(5-((theophyline-7-yl)methyl)-4-ethyl)-1,2,4-triazole-3-ylthio)acetyl)isonicotinohydrozide
Авторы: Gotsulya, A. S.
Zazhzharskiy, V. V.
Davydenko, P. O.
Kulishenko, O. M.
Parchenko, V. V.
Bushuieva, I. V.
Grynchyshyn, N. M.
Gutyj, B. V.
Magrelo, N. V.
Prysyaznyuk, V. Y.
Sus, H. V.
Vus, U. M.
Гоцуля, Андрій Сергійович
Зажжарський, В. В.
Давиденко, П. О.
Кулішенко, О. М.
Парченко, Володимир Володимирович
Бушуєва, Інна Володимирівна
Гринчишин, Н. М.
Гутий, Б. В.
Магрело, Н. В.
Присязнюк, В. Й.
Сус, Х. В.
Вус, У. М.
Ключевые слова: tuberculosis
experimental model
rabbits
treatment
1,2,4-triazole
Issue Date: 2021
Библиографическое описание: Experimental simulation of tuberculosis and its features in rabbits under conditions of isoniazid and N'-(2-(5-((theophyline-7-yl)methyl)-4-ethyl)-1,2,4-triazole-3-ylthio)acetyl)isonicotinohydrozide / A. S. Gotsulya, V. V. Zazhzharskiy, P. O. Davydenko, O. M. Kulishenko, V. V. Parchenko, I. V. Bushuieva, N. M. Grynchyshyn, B. V. Gutyj, N. V. Magrelo, V. Y. Prysyaznyuk, H. V. Sus, U. M. Vus // Ukrainian Journal of Ecology. - 2021. - Vol. 11, № 3. -P. 135-140. - ttps://doi.org/10.15421/ 2021_154
Аннотация: The results of morpho-biochemical studies of tuberculosis inflammation in rabbits in an experimental model with comparative isoniazid treatment and N'-(2-(5-((theophylline-7-yl)methyl)-4-ethyl-1,2,4-triazole-3-ylthio)acetyl)isonicotinohydrazide. It was found that subcutaneous administration of N'-(2-(5-((theophylline-7-yl)methyl)-4-ethyl-1,2,4-triazole-3-ylthio)acetyl)isonicotinohydrazide at a dose of 10 mg/kg body weight leads to the absence of specific and nonspecific manifestations of inflammation in the lungs, liver, kidneys and spleen. The calculated value of the drug indicates a high degree of safety N'-(2-(5-((theophylline-7-yl)methyl)-4-ethyl-1,2,4-triazole-3- ylthio)acetyl)isonicotino-hydrazide and its prospects for veterinary practice as an effective and safe tuberculocidal drug
URI: http://dspace.zsmu.edu.ua/handle/123456789/14005
Appears in Collections:Наукові праці. (Природничих дисциплін)

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