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Наукові праці. (Природничих дисциплін) >
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Название: | Experimental simulation of tuberculosis and its features in rabbits under conditions of isoniazid and N'-(2-(5-((theophyline-7-yl)methyl)-4-ethyl)-1,2,4-triazole-3-ylthio)acetyl)isonicotinohydrozide |
Авторы: | Gotsulya, A. S. Zazhzharskiy, V. V. Davydenko, P. O. Kulishenko, O. M. Parchenko, V. V. Bushuieva, I. V. Grynchyshyn, N. M. Gutyj, B. V. Magrelo, N. V. Prysyaznyuk, V. Y. Sus, H. V. Vus, U. M. Гоцуля, Андрій Сергійович Зажжарський, В. В. Давиденко, П. О. Кулішенко, О. М. Парченко, Володимир Володимирович Бушуєва, Інна Володимирівна Гринчишин, Н. М. Гутий, Б. В. Магрело, Н. В. Присязнюк, В. Й. Сус, Х. В. Вус, У. М. |
Ключевые слова: | tuberculosis experimental model rabbits treatment 1,2,4-triazole |
Issue Date: | 2021 |
Библиографическое описание: | Experimental simulation of tuberculosis and its features in rabbits under conditions of isoniazid and N'-(2-(5-((theophyline-7-yl)methyl)-4-ethyl)-1,2,4-triazole-3-ylthio)acetyl)isonicotinohydrozide / A. S. Gotsulya, V. V. Zazhzharskiy, P. O. Davydenko, O. M. Kulishenko, V. V. Parchenko, I. V. Bushuieva, N. M. Grynchyshyn, B. V. Gutyj, N. V. Magrelo, V. Y. Prysyaznyuk, H. V. Sus, U. M. Vus // Ukrainian Journal of Ecology. - 2021. - Vol. 11, № 3. -P. 135-140. - ttps://doi.org/10.15421/ 2021_154 |
Аннотация: | The results of morpho-biochemical studies of tuberculosis inflammation in rabbits in an experimental model with comparative
isoniazid treatment and N'-(2-(5-((theophylline-7-yl)methyl)-4-ethyl-1,2,4-triazole-3-ylthio)acetyl)isonicotinohydrazide. It was
found that subcutaneous administration of N'-(2-(5-((theophylline-7-yl)methyl)-4-ethyl-1,2,4-triazole-3-ylthio)acetyl)isonicotinohydrazide at a
dose of 10 mg/kg body weight leads to the absence of specific and nonspecific manifestations of inflammation in the lungs, liver, kidneys
and spleen. The calculated value of the drug indicates a high degree of safety N'-(2-(5-((theophylline-7-yl)methyl)-4-ethyl-1,2,4-triazole-3-
ylthio)acetyl)isonicotino-hydrazide and its prospects for veterinary practice as an effective and safe tuberculocidal drug |
URI: | http://dspace.zsmu.edu.ua/handle/123456789/14005 |
Appears in Collections: | Наукові праці. (Природничих дисциплін)
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