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Please use this identifier to cite or link to this item: http://dspace.zsmu.edu.ua/handle/123456789/14158

Название: Study of the structure of products of interaction between some naphthoquinone derivatives and pharmaceutical substances
Авторы: Donchenko, А.
Miedviediev, K.
Voskoboynik, O.
Vasyuk, S.
Kovalenko, S.
Донченко, Анастасія Олександрівна
Мєдвєдєва, Катерина Павлівна
Воскобойник, О. Ю.
Васюк, Світлана Олександрівна
Коваленко, Сергій Іванович
Ключевые слова: Acetylcysteine
β-alanine
taurine
naphthoquinone derivatives
reaction products
Issue Date: 2021
Библиографическое описание: Study of the structure of products of interaction between some naphthoquinone derivatives and pharmaceutical substances / А. Donchenko, K. Miedviedieva, O. Voskoboynik, S. Vasyuk, S. Kovalenko // Ankara Üniversitesi Eczacılık Fakültesi Dergisi. - 2021. - Vol. 45, Iss. 2. - P. 321-331. - https://doi.org/10.33483/jfpau.835875
Аннотация: The purpose of the present work is to detail а study of the interaction between naphthoquinonebased analytical reagents and such pharmacologically active ingredients as acetylcysteine, β-alanine and taurine (2-aminoethanesulfonic acid) including the isolation and structure elucidation of the formed products. Material and Method: UV-visible spectrophotometry was applied to determine the stoichiometric coefficients of reactants in reactions between the pharmaceutical substances and naphthoquinone derivatives. 1Н NMR-spectroscopy, IR spectroscopy, сhromatomass-spectrometry were used to prove the structure of the reaction products. Result and Discussion: The stoichiometric relationships of the reactants in the investigated medicinal substances reactions with quinone derivatives were determined by the methods of saturation and continuous changes. They are 1:1 in each case. According to the determined relationships of components reaction and optimal conditions for reactions path, the products of interaction of acetylcysteine with 2,3-dichloro-1,4-naphthoquinone and taurine, β-alanine with sodium 1,2-naphthoquinone-4-sulfonate were isolated and identified. In order to establish the structure of the compounds, the 1Н NMR-spectroscopy, IR spectroscopy, сhromatomass-spectrometry were used.
URI: http://dspace.zsmu.edu.ua/handle/123456789/14158
Appears in Collections:Наукові праці. (Аналітична хімія)

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