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Please use this identifier to cite or link to this item: http://dspace.zsmu.edu.ua/handle/123456789/14217

Название: 2-[(3-Aminoalkyl-(alkaryl-,aryl-))- 1 H-1,2,4-triazol-5-yl]anilines: synthesis and anticonvulsant activity
Авторы: Martynenko, Yu.
Berest, G.
Bukhtiyarova, N.
Belenichev, I. F.
Voskoboinik, O.
Kovalenkо, S.
Мартиненко, Юлія Вікторівна
Берест, Галина Григорівна
Бухтіярова, Ніна Вікторівна
Беленічев, І.
Воскобойнік, Олексій Юрійович
Коваленко, Сергій Іванович
Ключевые слова: N -acylated{([1,2,4]triazolo[1,5- c ]quinazolin-2-yl)alkyl-(alkaryl-, aryl-)}amines
2-[(3-aminoalkyl-(alkaryl-, aryl-))-1H -1,2,4-triazolo]anilines
acidic hydrolysis
anticonvulsant activity
Issue Date: 2020
Библиографическое описание: 2-[(3-Aminoalkyl-(alkaryl-,aryl-))- 1 H-1,2,4-triazol-5-yl]anilines: synthesis and anticonvulsant activity / Yu. Martynenko, G. Berest, N. Bukhtiyarova, I. Belenichev, O. Voskoboinik, S. Kovalenkо // Turkish Journal of Chemistry. - 2020. - Vol. 44, № 3. -P. 746-755. - https://doi.org/10.3906/kim-2002-24
Аннотация: : The presented work is devoted to the development of synthesis methods for novel 2-[(3-aminoalkyl-(alkaryl-, aryl-))-1H -1,2,4-triazolo]anilines. Abovementioned compounds were obtained via hydrazinolysis (Ing-Manske procedure) and acid hydrolysis of corresponding N -acylated{([1,2,4]triazolo[1,5- c ]quinazolin-2-yl)alkyl-(alkaryl-, aryl-)}amines. The regioselectivity of hydrazinolysis and hydrolysis were established. The features of spectral characteristics were studied and discussed. Characteristic patterns of protons signals splitting in 1 H NMR of the synthesized compounds were established. The effect of the synthesized compounds on the pentylenetetrazol seizures was studied. It was found that according to some indicators, anticonvulsant activity of 2-[(3-aminoalkyl-(alkaryl-, aryl-))-1H -1,2,4-triazolo]anilines superior or comparable with effect of the reference drug “Lamotrigine”. It is a valid argument for their further structural modification, in-depth study of activity mechanisms and further study of anticonvulsant activity on other experimental seizures models.
URI: http://dspace.zsmu.edu.ua/handle/123456789/14217
Appears in Collections:Наукові праці. (Органічна хімія)

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