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Название: | Medullary vasomotor center: a modern view of the structure, function and its role in arterial hypertension pathogenesis |
Авторы: | Danukalo, M. V. Hancheva, O. V. Melnikova, O. V. Isachenko, М. I. Данукало, Максим Вікторович Ганчева, Ольга Вікторівна Мельнікова, Ольга Валеріївна Ісаченко, Марія Ігорівна |
Ключевые слова: | brainstem baroreflex dorsal vagal complex caudal ventrolateral medulla rostral ventrolateral medulla locus coeruleus arterial hypertension |
Дата публикации: | 2021 |
Библиографическое описание: | Medullary vasomotor center: a modern view of the structure, function and its role in arterial hypertension pathogenesis / M. V. Danukalo, O. V. Hancheva, O. V. Melnikova, М. I. Isachenko // Journal of Education, Health and Sport. - 2021. - Vol. 11, № 8. -P. 491-503. - http://dx.doi.org/10.12775/JEHS.2021.11.08.055 |
Аннотация: | The medullary centers of blood pressure regulation have been in the field of vision of
both physiologists and doctors for a very long period of time. This is mainly due to the
abundance of structures and interstructural interactions in the brain stem, involved in
maintaining blood pressure. Advances in research technology open new opportunities these
days to look at this problem from a different angle. Moreover, research of medullary centers
of blood pressure regulation will make it possible to understand better the mechanisms of persistent increase in blood pressure, which will create the preconditions for the formation of
new pathogenetically substantiated therapeutic approaches in the treatment of such a
widespread and dangerous pathology as arterial hypertension. Therefore, the aim of this work
was to analyze modern views about the structure and composition of the medullary vasomotor
center, its functions and its role in the arterial hypertension development. To achieve this
goal, the search by keywords: arterial hypertension, baroreflex, NTS, DMN, RVLM, CVLM,
CPA, SHR, LC and analysis of scientific articles from the databases of search engines Google
Scholar, Web of Science, Pub Med was done. Conclusions: 1. The analysis of literature
sources showed that the concept of "medullar vasomotor center" includes a number of
brainstem formations, the most studied of which are the structures of the dorsal complex of
the vagus nerve (the nucleus of the solitary tract, the dorsal motor nucleus, area postrema), the
rostral and caudal ventrolateral regions of medulla, caudal pressor area, noradrenergic
structures of the brainstem, in particular the locus coeruleus, as the biggest of them. 2.
According to literary sources, arterial hypertension is accompanied by the changes in the
morphofunctional state of the above-mentioned structures. The most common mechanisms
are violation of the neurotransmitter composition within the structure and the
neuroinflammatory process. |
URI: | http://dspace.zsmu.edu.ua/handle/123456789/15281 |
Располагается в коллекциях: | Наукові праці. (Патологічна фізіологія)
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