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Название: | Development and validation of clopidogrel bisulphate determination in bulk by UV spectrophotometric method |
Авторы: | Antypenko, L. Gladysheva, S. Vasyuk, S. Гладишева, Світлана Анатоліївна Васюк, Світлана Олександрівна |
Ключевые слова: | clopidogrel bisulphate validation UV-spectrophotometry |
Issue Date: | 2016 |
Библиографическое описание: | Antypenko L. Development and validation of clopidogrel bisulphate determination in bulk by UV spectrophotometric method / L. Antypenko, S. Gladysheva, S. Vasyuk // Scripta Scientifica Pharmaceutica. - 2016. - Vol. 3, № 2. - PР. 17-22. - http://dx.doi.org/10.14748/ssp.v3i2.1704 |
Аннотация: | A simple, rapid, sensitive and low-cost UV-spectrophotometric method has been developed for the quantification of clopidogrel bisulphate in pure substance. It was validated for linearity, range, accuracy, precision,
ruggedness and robustness. The valid maximum absorbance was recorded at the 203 nm wavelength in the
concentration ranges 1.0-2.6 mg/100mL of clopidogrel bisulphate in methanol solution after 15 min stirring.
The limit of detection was found to be 0.59 mg/100mL, while the limit of quantification was 1.78mg/100mL.
The calibration curve was linear with r2
=0.9929. The proposed technique could be successfully used for
the determination of clopidogrel bisulphate in bulk in small laboratories without LC−MS spectrometer or
HPLC-UV chromatograph, as well as for future pharmacokinetic studies in pharmaceutical dosage forms. |
URI: | http://dspace.zsmu.edu.ua/handle/123456789/15476 |
Appears in Collections: | Наукові праці. (УЕФ та фарм. технології ФПО) Наукові праці. (Аналітична хімія)
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