Mycostatic activity of extracts from leaves of plantago media L. and Plantago altissima L.

Abstract

A variety of drugs are widely used to treat fungal infections. Mostly they are products of chemical synthesis, but recently, due to the increased resistance of fungi to many synthetic drugs, the relevance of the use of herbal remedies in the complex treatment of both skin infections and deep mycoses has been increasing. The aim of our research was to study the chemical composition of the lyophilic extracts of Plantago mediaand Plantago altissimaof the flora of Ukraine by HPLC and GLC-MS methods and also mycostatic activity of ethanol and lyophilic extracts of the studied plants. As a result of the research, aucubin iridoid was detected in the lyophilic extracts of both species. There were also detected 15 polyphenolic compounds among which prevails acteoside, plantamayoside, ferulic and chlorogenic acid. Alcohol and lyophilic extracts of P. mediaand P. altissima showed mycostatic activity to all studied strains of yeast, dermatophytic fungi and aspergillus. The mycostatic effect of alcoholic extracts of P.mediaand P. altissimawas more evident in comparison with the mycostatic effect of lyophilic extracts. The most evident antifungal effect was presented by alcoholic extract of P. mediain relation to the clinical strain of Aspergillus oryzae (18.0±1.0 mm), and alcoholic extract of P. altissimato the clinical strain of Malassezia sp. (18.0±0.5 mm). The data obtained indicate a wide range of mycostatic effects of Plantago mediaand Plantago altissimaextracts and the prospectivity of these objects for practical use in medicine.