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Please use this identifier to cite or link to this item: http://dspace.zsmu.edu.ua/handle/123456789/2308

Название: Reduction of apoptotic death of neurons-1 zone of hippocampus of rats in the condition of prenatal chronic alcoholisation by cerebrocurin and tiocetam
Авторы: Belenichev, I. F.
Sokolik, E. P.
Egorov, A. N.
Бєленiчев, Iгор Федорович
Соколик, Олена Петрiвна
Єгоров, Олександр Миколайович
Ключевые слова: Prenatal alcoholism
Cerebrocurin
Tiocetam
CA-1 zone of hippocampus
Apoptosis
Issue Date: 2013
Библиографическое описание: Belenichev I. F. Reduction of apoptotic death of neurons-1 zone of hippocampus of rats in the condition of prenatal chronic alcoholisation by cerebrocurin and tiocetam / I. F. Belenichev, E. P. Sokolik, A. N. Egorov // Elixir Pharmacy. – 2013. - 65A. – Р. 20005-20008
Аннотация: Our research found that prenatal alcoholism leads to increase of NO induction and nitrosine stress in the brain of newborn rats, evidenced by the increasing of nitrotyrosine in citosole and mitochondria. By adjusting the ratio of mitochondrial/cytosole concentrations of NO and reactive oxygen forms, cerebrocurin and tiocetam limited the effect of these compounds on the activation or deprivation of the processes of gene expression, transcription and translation in neuronal cells of brain of animals that survived the prenatal alcoholism and, thus, may provide the normal development of the cognitive functions of central nervous system. And increased expression of the protein bcl-2 in the group of animals receiving cerebrocurin and tiocetam, testifies to the activation of antiapoptosis protection of damaged neurons.
URI: http://dspace.zsmu.edu.ua/handle/123456789/2308
ISSN: 2229-712Х
Appears in Collections:Наукові праці. (Фармакологія та МР)

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