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Please use this identifier to cite or link to this item: http://dspace.zsmu.edu.ua/handle/123456789/2319

Название: Disturbance of HSP70 Chaperone Activity Is a Possible Mechanism of Mitochondrial Dysfunction
Авторы: Belenichev, I. F.
Pavlov, S. V.
Sokolik, E. P.
Бєленічев, Ігор Федорович
Павлов, Сергій Васильович
Соколик, Олена Петрівна
Ключевые слова: mitochondrial dysfunction
heat shock proteins
chaperones
ischemia
Issue Date: 2011
Издатель: Pleiades Publishing
Библиографическое описание: Belenichev I. F. Disturbance of HSP70 Chaperone Activity Is a Possible Mechanism of Mitochondrial Dysfunction / I. F. Belenichev, S. V. Pavlov, E. P. Sokolik // Neurochemical Journal. – 2011. – Vol. 5, № 4. – P. 251-256.
Аннотация: We studied the involvement of HSP70 and Hif1b genes in the development of pathological changes in the brains of experimental animals during ischemia. We found neuro- and mitoprotective characteristics of heat shock protein HSP70 and Hif1b in vitro and under cerebral ischemia due to stabilization of molecules damaged by oxidation, inhibition of nitrosative and oxidative stress and mitoprotective action directed to amelioration of mitochondrial dysfuction. The protective role of these proteins provides a new direction for the development of novel neuroprotective drugs that protect or modulate the genes that encode these proteins.
URI: http://dspace.zsmu.edu.ua/handle/123456789/2319
ISSN: 1819 7124
Appears in Collections:Наукові праці. (Фармакологія та МР)

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