Neurogenic inflammation indices in children of primary school age with recurrent upper respiratory tract infection

Abstract

The children of primary school are prone to frequent respiratory diseases. In the structure of general morbidity, this pathology ranks first. Their prevalence is more than 60%, which leads to frequent school absences, lack of active games and outdoor walks, in view of this the child’s time increases over the means of mass electronic communication and electronic games, leading to high adherence, up to and including to addiction, forming in the child hypodynamia and increased psycho-emotional stress, which together has a negative impact on the functioning of the regulatory systems of the child’s body. Recurrent upper respiratory tract infection contributes to the tension of neuro-endocrine-immune regulation, leading to an imbalance of neuropeptides - mediators of neurogenic inflammation. The aim of this work is to study the indices of neurogenic inflammation in children of primary school with recurrent upper respiratory tract infection. We examined 130 children with upper respiratory tract infection at the age of 6 to 9 years in the period of somatic well-being. The serum content of vasoactive intestinal peptide, substance P and NO final stable metabolites in children was analyzed. An increase of serum substance P in of schoolchildren with upper respiratory tract infection was found, which had statistically significant differences with the indices of healthy children (p <0.05). It has been proved that in children with upper respiratory tract infection due to an increase in serum NO final stable metabolites, which have a pro-inflammatory orientation. It was found a significant decrease of the serum vasoactive intestinal peptide content in children with upper respiratory tract infection. Children with upper respiratory tract infection upper respiratory tract infection in the period of somatic well-being have an increase in the concentration of serum substance P and final stable metabolites NO. In the period of somatic well-being children of primary school with upper respiratory tract infection have a decrease of the vasoactive intestinal peptide serum level.