Investigation of conditional differential inhibition in the cerebral cortex in middle-aged male patients with essential hypertension stage ii during operative activity

Abstract

The study aimed to investigate the conditional differential inhibition in the cerebral cortex during operative activity and its influence on the cardiohemodynamics parameters in middleaged male patients with essential hypertension stage II. In total 60 male middle age patients with essential hypertension stage II, which were 6 months prior to enrollment in the study, did not receive antihypertensive therapy, were examined. Conventional differential inhibition in the cerebral cortex at operational activities was studied by means of Anfimov’s test; blood pressure and heart rate data were collected at the initial state, immediately right after and in 3 minutes after Anfimov’s test. According to Anfimov’s test, 3 types of mental task performance were revealed. Low mental task performance was determined at 45% (n=27), middle one – at 43.3% (n=26) and high level mental task performance was characteristic of 11.7% (n=7) patients. The general patterns of minute dynamics of mental task performance in each group were revealed. The study of the influence of conditional differential inhibition in the cerebral cortex during Anfimov’s test allowed to reveal 2 main types of blood pressure and heart rate parameters changes – normotonic and hypertonic. There were no significant changes in blood pressure and heart rate in patients with normotonic type of response (n=13; 21.7% of the total number of patients). The second type of reaction, hypertonic, was detected in 47 patients (78.3%) and was characterized by a significant increase in blood pressure and heart rate by more than 5% of the initial values. Obtained data indicate a decreased overall level of mental task performance in patients with essential hypertension of II stage, the imbalance of processes of excitation and inhibition in cerebral cortex, blood pressure regulation imbalance, stagnation of processes of excitation in cerebral cortex, the inertness of the system regulating blood pressure.