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Please use this identifier to cite or link to this item: http://dspace.zsmu.edu.ua/handle/123456789/3807

Название: Can Osteoprotegerin be a Target of Therapy in Type 2 Diabetes Mellitus?
Авторы: Berezin, A. E.
Березін, Олександр Євгенійович
Ключевые слова: Diabetes mellitus
Osteoprotegerin
Cardiovascular events
Target therapy
Prediction
Issue Date: 2016
Библиографическое описание: Berezin A. E. Can Osteoprotegerin be a Target of Therapy in Type 2 Diabetes Mellitus? / A. E. Berezin // Metabolomics. - 2016. - Vol. 6, № 2. – [рр. 5]. - doi:10.4172/2153-0769.1000172
Аннотация: Osteoprotegerin (OPG) is a soluble member of the tumor necrosis factor receptor superfamily, which exhibits the close link to Cardiovascular (CV) disease in Type 2 Diabetes Mellitus (T2DM). Recent clinical studies have been shown that elevated OPG might be a marker of vascular calcification / remodeling and CV events and CV mortality in T2DM without known CV disease. However, it remains unclear whether OPG would be a target for therapy of diabetics with antidiabetic drugs and statins. The aim of the mini review: to summarize knowledge with respect to OPG utilization as predictor of CV adverse effects and as a target of therapy in T2DM. The review is discussed the evidence regarding possibility to prevent microvascular and macrovascular complications in diabetics through control of OPG level as a target in therapy. Although there are not irresistible findings that the post-treatment OPG level in diabetics and CV events might be related, possibility to use OPG for risk stratification of vascular remodeling / ectopic calcification and CV-related mortality in T2DM appears to be attractive. The future investigations are needed to explain whether serum OPG would be informative for biomarker-guided therapy in T2DM individuals.
URI: http://dspace.zsmu.edu.ua/handle/123456789/3807
ISSN: 2153-0769
Appears in Collections:Наукові праці. (ВХ-2)

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