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Please use this identifier to cite or link to this item: http://dspace.zsmu.edu.ua/handle/123456789/5098

Название: Benzo[e][1,2,4]triazino[2,3-c][1,2,3]triazin-2-ones electro-deficient heterocyclic compounds with promising anticancer activity
Авторы: Voskoboynik, O. Y.
Kovalenko, S. I.
Shishkina, S. V.
Воскобойнік, Олексій Юрійович
Коваленко, Сергій Іванович
Шишкіна, Світлана В.
Ключевые слова: anticancer activity
benzo[e][1,2,4]triazino[2,3- c][1,2,3]triazines
heterocyclic compounds
Issue Date: 2016
Библиографическое описание: Voskoboynik O. Y. Benzo[e][1,2,4]triazino[2,3-c][1,2,3]triazin-2-ones electro-deficient heterocyclic compounds with promising anticancer activity / O. Y. Voskoboynik, S. I. Kovalenko, S. V. Shishkina // Heterocyclic Communications – 2016. – Vol. 22, Issue 3. – P. 137-141. DOI 10.1515/hc-2015-0190
Аннотация: The synthesis and antitumor activity of substituted benzo[e] 1,2,4]triazino[2,3-c][1,2,3]triazin-2-ones – novel electroeficient tricyclic compounds – are described. These compounds were prepared by treatment of 3-(2-amino-3-R2-5-R3-phenyl)-6-R1-1,2,4-triazin-5(2H)-ones with sodium nitrite in acetic acid. Spectral properties of synthesized compounds were studied and compared with spectral data of known 3-R-8-R1-10-R2-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones. These compounds are promising antitumor agents. The most active anticancer compound 3d was studied in dose-depended anticancer activity assay and its selective growth inhibition against breast cancer MDA-MB-468 cell line was established (GI50 = 0.41 μm)
URI: http://dspace.zsmu.edu.ua/handle/123456789/5098
Appears in Collections:Наукові праці. (Органічна хімія)

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