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Please use this identifier to cite or link to this item: http://dspace.zsmu.edu.ua/handle/123456789/5127

Название: Synthesis and Hydrolytic Cleavage of Tetrazolo[1,5-c]Quinazolines
Авторы: Antypenko, O. M.
Kovalenko, S. I.
Karpenko, O. V.
Антипенко, Олексій Миколайович
Коваленко, Сергій Іванович
Карпенко, О. В.
Ключевые слова: Tetrazolo[1,5-c]quinazolines
2-(1H-tetrazolo-5-yl)aniline
hydrolytic cleavage
Issue Date: 29-Feb-2016
Издатель: Marcel Dekker Inc.
Библиографическое описание: Antypenko O. M. Synthesis and Hydrolytic Cleavage of Tetrazolo[1,5-c]Quinazolines / O. M. Antypenko, S. I. Kovalenko O. V. Karpenko // Synthetic Communications. - 2016. - Vol. 46, Issue 6. - P. 551-555. DOI: 10.1080/00397911.2016.1156131
Аннотация: Substituted tetrazolo[1,5-c]quinazolines exhibit various biological activities. In particular, their cytostatic[1,2], anticancer[3,4], hypoglycemic[5], actoprotective[6], antimicrobial and bioluminescence-inhibitory potential[4,7] was studied. In addition, patents confirm bronchodilator[8,9] and fibrinolytic activity[10]. Other condensed tetrazoloquinazolines also showed high biological activity[11-13]. However, 7, 8, 9 and 10 substituted tetrazolo[1,5-c]quinazolines were insufficiently studied. Therefore, it was decided to synthesize a range of tetrazolo[1,5-c]quinazolines (2.1-2.8) and to study their behavior in hydrolytic cleavage reactions of the pyrimidine ring, which lead to the formation of 2-(1H-tetrazol-5-yl)anilines (3.1-3.10). As the latter were promising 1,5-binucleophiles, they could be used for [5+1]-cyclocondensation with electrophiles
URI: http://dspace.zsmu.edu.ua/handle/123456789/5127
ISSN: 0039-7911
Appears in Collections:Наукові праці. (Органічна хімія)

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