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Please use this identifier to cite or link to this item: http://dspace.zsmu.edu.ua/handle/123456789/5954

Название: Synthesis of 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones and their anticancer activity
Авторы: Antypenko, Oleksii
Kovalenko, Sergiy
Антипенко, Олексій Миколайович
Коваленко, Сергій Іванович
Ключевые слова: Anticancer activity
6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones
organic synthesis
Issue Date: 25-Mar-2016
Издатель: Acta Chimica Slovenica
Библиографическое описание: Synthesis of 6-N-R-Tetrazolo[1,5-c]quinazolin-5(6H)-ones and Their Anticancer Activity / O. Antypenko, S. Kovalenko, B. Rasulev, J. Leszczynski // Acta Chim. Slov. – 2016. - Vol. 63. – P. 638–645. DOI: 10.17344/acsi.2016.2464
Аннотация: Chemical compounds with tetrazole ring are very interesting systems that can be valuable in pharmaceutical and clinical applications, especially as anticancer agents. In this work, novel 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones were synthesized. A large set of IR, LC-, EI-MS, 1H, 13C NMR and elemental analysis data were collected and evaluated for their structures and purity. Details of synthesis, namely the N-alkylation, are discussed, including reactions with secondary and tertiary amides. Four new synthesized compounds (2.7, 3.2, 5.2, 5.3) were tested in vitro for anticancer activity at 10 μM against 60 cell lines of nine different cancer types: leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate, and breast cancers. Further synthesis of substances within the series of substituted tetrazolo[1,5-c]quinazoline systems will be attempted to develop improved compounds with better anticancer activity.
URI: http://dspace.zsmu.edu.ua/handle/123456789/5954
Appears in Collections:Наукові праці. (Органічна хімія)

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