DSpace About DSpace Software
 

IRZSMU >
Кафедри >
Кафедра біологічної хімії >
Наукові праці. (Біохімія) >

Please use this identifier to cite or link to this item: http://dspace.zsmu.edu.ua/handle/123456789/7494

Название: Some aspects of in vitro studies of neurotoxicity: from choice of biochemical and molecular markers to the confirmation of their informativity
Авторы: Chekman, I. S.
Trachtenberg, I. М.
Belenichev, I. F.
Buhtiyarova, N. V.
Gorchakova, N. A.
Levich, S. V.
Бєленічев, Ігор Федорович
Бухтіярова, Ніна Вікторівна
Левіч, Сергій Вадимович
Ключевые слова: neurotoxicity
in vitro studies
markers
reduced glutathione
nitrotyrosine
Issue Date: 2017
Издатель: Bulgaria: Hikari Ltd
Библиографическое описание: Some aspects of in vitro studies of neurotoxicity: from choice of biochemical and molecular markers to the confirmation of their informativity / I. S. Chekman, I. М. Trachtenberg, I. F. Belenichev, N. V. Buhtiyarova, N. A. Gorchakova, S. V. Levich // Biological markers and guided therapy. – 2017. – Vol. 4, № 1. – P. 71-90.
Аннотация: The use of laboratory animals in pharmacological and toxicological studies is axiomatic from the point of experimental science and will always be conducted. But these studies are laborious, require additional personnel, the presence of a vivarium, cause the suffering of animals and their death. Therefore, since the late 80's of the last century in the scientific community of Europe and the US actively discusses the issue of toxicological studies in vitro and, in particular, neurotoxicological studies in vitro. But the use of various molecular and biochemical markers of the central nervous system in neurotoxicological studies in vitro, as well as the morphometric parameters of a neuron, can be difficult, because they can be changed by neuroprotective, and not neurotoxic, action of a potential drug. That's why, it is necessary to identify and use molecular or biochemical markers, that make it possible to clearly judge about only the neurotoxicity of the drugs.
URI: http://dspace.zsmu.edu.ua/handle/123456789/7494
Appears in Collections:Наукові праці. (Лабораторна діагностика)
Наукові праці. (Фармакологія та МР)
Наукові праці. (Біохімія)

Files in This Item:

File Description SizeFormat
belenichevBMGT1-2017-2.pdf576,84 kBAdobe PDFView/Open
View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback