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Please use this identifier to cite or link to this item: http://dspace.zsmu.edu.ua/handle/123456789/7679

Название: Antioxidant effect of xanthinyl-7-acetic acid derivative on sod activity under condition of nitrosative stress in vitro
Авторы: Belenichev, Igor F.
Aleksandrova, Katherine V.
Buhtiyarova, Nina V.
Levich, Sergii V.
Nosach, Svitlana G.
Sinchenko, Darja N.
Бєленічев, Ігор Федорович
Александрова, Катерина Вячеславівна
Бухтіярова, Ніна Вікторівна
Левіч, Сергій Вадимович
Носач, Світлана Григорівна
Сінченко, Дар'я Миколаївна
Ключевые слова: nitric oxide
sodium nitroprusside
superoxide dismutase
theophyl-linyl-7-acetic acid derivative
Issue Date: 2016
Издатель: Bulgaria: Hikari Ltd
Библиографическое описание: Antioxidant effect of xanthinyl-7-acetic acid derivative on sod activity under condition of nitrosative stress in vitro / I. F. Belenichev, K. V. Aleksandrova, N. V. Buhtiyarova, S. V. Levich, S. G. Nosach, D. N. Sinchenko // Biological markers and guided therapy. – 2016. – Vol. 3, № 1. – 139-145. http://dx.doi.org/10.12988/bmgt.2016.6412
Аннотация: During recent years NO and ONOO– are considered to be a key patho-physiological factor of some basic diseases of the central nervous system (ische-mia, stroke, neurodegenerative diseases, etc.). Therefore search for antioxidants which would reduce NO and ONOO– toxicity seems to be very topical nowadays. In this study, we provide experimental evidence of antioxidant activity of the hy-drazide of Obtained results showed that compound C-3 had pronounced antioxidant properties in conditions of nitrosative stress modeling and caused protective effect on SOD activity. This is the experimental rationale of further investigation of C-3 compound properties in vivo as potential antioxidant. 8-benzylaminotheophyllinyl-7-acetic acid (C-3 compound) (synthe-sized at Department of Biological Chemistry, Zaporozhye State Medical Universi-ty, Zaporozhye, Ukraine). The investigation was conducted in vitro in the test of NO formation. Au-thors suggest that inactivation of superoxide dismutase (SOD) under condition of nitrosative stress plays an important role. We studied effect of C-3 compound on SOD activity under condition of excessive NO and ONOO–production. NO in-duction was performed under the action of light on sodium nitroprusside Na2[Fe(NO)(CN)5]2H2O. The investigation of substances was carried out in su-pernatant obtained from the brain of white Wistar rats (male, 200-250 g). For ni-trosive stress modeling dinitrosyl-Fe2+ cystein complex was utilized.
URI: http://dspace.zsmu.edu.ua/handle/123456789/7679
Appears in Collections:Наукові праці. (Лабораторна діагностика)
Наукові праці. (Біохімія)
Наукові праці. (Фармакологія та МР)

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