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Please use this identifier to cite or link to this item: http://dspace.zsmu.edu.ua/handle/123456789/7749

Название: The molecular and ultrastructural aspects of the formation of mitochondrial dysfunction in the modeling of chronic cerebral ischemia: the mitoprotective effects of angiolin
Авторы: Belenichev, I. F.
Mazur, I. A.
Kucherenko, L. I.
Nagornaya, E. A.
Gorbacheva, S. V.
Бєленічев, Ігор Федорович
Мазур, Іван Антонович
Кучеренко, Людмила Іванівна
Нагорна, Є. А.
Горбачова, Світлана Василівна
Бідненко, Олександр Сергійович
Bidnenko, A. S.
Ключевые слова: cerebral circulation disorder
heat shock proteins
mitochondrial dysfunctions
mitoprotective effect
mitoptosis
Angiolin
Issue Date: 2016
Издатель: Moscow: Pleiades Publishing, Ltd.
Библиографическое описание: The molecular and ultrastructural aspects of the formation of mitochondrial dysfunction in the modeling of chronic cerebral ischemia: the mitoprotective effects of angiolin / I. F. Belenichev, I. A. Mazur, L. I. Kucherenko, E. A. Nagornaya, S. V. Gorbacheva, A. S. Bidnenko // Neurochemical Journal. – 2016. – Vol. 10, №. 2. – P. 131-136. DOI: 10.1134/S1819712416010025
Аннотация: Abstract – Modeling of cerebral circulation disorder by bilateral occlusion of carotids was accompanied by formation of severe neurological symptoms and their preservation for up to 18 days of the experiment. We found a significant decrease in the level of the HSP70 heat shock protein and the formation of persistent mitochondrial dysfunction. Administration of Angiolin to experimental animals resulted in activation of the expression of the HSP70 gene in neurons and ultrastructural improvement of mitochondria and neurons of СА1 hippocampal zone. The substantial mitoprotective activity of Angiolin is based on its antioxidant activity and the ability to positively influence the activity of anaerobic glycolysis, thus stabilizing the cellular energy metabolism under conditions of ischemic injury.
URI: http://dspace.zsmu.edu.ua/handle/123456789/7749
ISSN: 1819-7124
Appears in Collections:Наукові праці. (Лабораторна діагностика)
Наукові праці. (Фармакологія та МР)
Наукові праці. (Фармацевтична хімія)

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