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Please use this identifier to cite or link to this item: http://dspace.zsmu.edu.ua/handle/123456789/9915

Название: Rat model of inflammatory bowel disease modulate aryl hydrocarbon receptor expression
Авторы: Zherebiatiev, A. S.
Жеребятьєв, Олександр Сергійович
Ключевые слова: тези доповідей
Issue Date: 2019
Издатель: Запорізький державний медичний університет
Библиографическое описание: Zherebiatiev A. S. Rat model of inflammatory bowel disease modulate aryl hydrocarbon receptor expression / A. S. Zherebiatiev // Актуальні питання сучасної медицини і фармації : зб. тез доп. наук.-практ. конф. з міжнар. участю молодих вчених та студ., 13-17 трав. 2019 р. - Запоріжжя, 2019. – С. 7-8.
Аннотация: Background and Aim: The pathogenesis of inflammatory bowel disease is complex and multifactorial. Studies have led to the current concept that aryl hydrocarbon receptors have recently emerged as a critical physiological regulator of immune responses affecting both innate and adaptive systems. We studied the possibility of simvastatin and antagonist of receptors of interleukin-1 for pharmacological correction of colitis in rats with a focus on the expression intensity studies of AhR with lymphocytes of colon. Materials and Methods. Experiments were carried out on male Wistar rats aged 8 months (body mass 260–285 g). Rats were divided into four experimental groups: group 1 ― control; group 2 ― rats with oxazolone-induced colitis; group 3 ― rats given simvastatin (20 mg/kg, for 5 days, intraperitoneally) ; group 4 ― rats given antagonist of receptors of interleukin-1 (3 mg/kg, for 5 days, subcutaneously). The AhR immunopositive lymphocytes were determined using an indirect immunofluorescence technique with using a monoclonal rat antibody.
URI: http://dspace.zsmu.edu.ua/handle/123456789/9915
Appears in Collections:Наукові праці. (Мікробіологія)

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